The Suprosa Cluster

Galaxies in the cluster:

G1: The largest and the galaxy humans originated in
G2: The smalles and is roughly 'in between' the other two major galaxies
G3: Located across a vast void of space from G1
G4: A tiny galaxy orbiting the cluster - about the size of LMC
G5: Another tiny galaxy orbiting the cluster - nearly 2x the size of LMC
The Gap: A nearly empty void between the galxies G1 and G3 where approxamately 300 total stars are known to exist.

Galactic Size

G1: 181k Light years across
G2: 100k LY across
G3: 123k LY across
G4: 31k LY across
G5: 59k LY across
The Gap: About 220k at the widest tips, 120k at the closest approaches

Total number of settled worlds:

7000

Total number of star systems with some sort of settlement (space station, research base, etc)

350,000

Galactic Human Population:

10+ trillion

Major Powers:

Alfadorian Star Empire - Mostly in G1
Conglomerate of Ionasa - Mostly in G3
Federation of Alacia - Mostly in G2

Technology progression:

Progress: Stagnation
Kardashev Scale: 2.3 - 2.4
Antimatter Reactors are unstable and have been in development for 100+ years but still aren't commercially viable.
Dyson swarms on some worlds.
Energy to Matter replication at industrial / military level, not consumer level
Universal Translation techology exists
Antimatter planet-killers exist
FTL - Able to travel between galaxies (with major limitations / requirements)\
Terrraforming commercially viable - takes 30-100 years depending on planet size
Artifical Gravity exists - common use

Aliens:

Variable. Can exist, or not exist! Currently configured that humans are the only intelligent species - but there are lesser developed species throughout the galaxy being observed under a non-intervention policy. There are also ancient ruins of spacefaring races throughout the galaxy.

Small Arms:

Ballistics and directed energy weapons
Plasma and particle accelerator weapons exist but are expensive
Disruptors exist but are banned in most places, and are unstable

Personal Armor

Personal Shields are common
Armor is able to withstand varying degrees of punishment based on function
Large Arms
Similar to small arms.
Antimatter weapons are WMDs.

Melee Weapons

Not extremely common, but both kinetic cand energy based weapons exist
Specialized vibro blades are used by assassins
Energy blades are unstable and are mostly used for industrial or specialized engineering work (hull breaches)
More common to use on heavily modified/augmented people

Body Modification

Capabilities similar to Cyberpunk settings but exceptionally more robust and safer.
Bioware
Cyberware
Genetic Modification
Cloning

Supernatural

Psionics are extremely rare - appx 1 in 1 billion humans are Psions.
Psions can manipulate matter with their minds, interact with other intelligences by thought, and can perceive space/time in a unique way that allows them to understand where they are in the universe. Psions can communicate with eachother at any distance in real time.
Psions are becoming more common than ever, having once been rare enough to number in the hundreds only a century ago, there are roughly 5000 psions known, with many believed to also exist undocumented.

Artificial Gravity

Gravity can be generated in space ships, habitats, and on planets. Can increase or decrease.
Sub-Light speeds:
THe fastest sub-light speeds are usually in the range of 0.1% the speed of light. Acceleration, operational speeds, and other things vary ship to ship. Not taking into account acceleration and deceleration, a ship moving at sublight would take about two months to go from Earth to Jupiter (taking into account acceleration, deceleration, and flight adjustements).

FTL

Multiple varities based on use-case
Alcuberie Drive - Used for interplanetary travel. Highest speeds at rougly 2500 AU/hr. Most commercially avaiable ADs are 1000 AU/hr. Fastest accelerations are about 20 AU/m² and average are 4 AU/m². Average deceleration is about 450AU/m² and the fastest is about 3500AU/m² The average time it would take a ship to get to Pluto from Earth using an average commericial grade vessel: About 4 1/2 hours.
Jump Drive - Used for inter-system travel. Jump drives are very expensive. They function similarly to ADs, but require a different fuel source. Once a ship enters jump, it does not have a top speed and can accelerate continuously as long as it has enough fuel. The average rate of acceleration for a jump drive is 1000 AU/m² and the average deceleration is 15000AU/m². This enables a jump-drive enabled ship, on average, to theoretically make the jump between G1 and G3 in roughly 65 hours assuming it has the fuel to accelerate continuously through the jump. Maintaining speed requires almost no fuel and deceleration requires less than accelerating. Jumping is extremely dangerous, and is not practiced commonly. Used by military, crimninals, and deep space explorers. Jump drives are generally considered too inaccurate for interplanetary travel but can be used by skilled pilots to cut travel times down to seconds.
Gate System - Used for inter-system travel. Gates provide nearly instantaneous travel between two points in space. A gate propels a ship to a speed of 1000 LY/hr, but only to another connected Gate. Gates are how most FTL Communications and interstellar travel is conducted. Gates have 'tunnels' where matter cannot enter from the outside, and are effectively perfect vacuums with zero chance of matter collision.
Particle Displacement System - Shields are able to gravitationally affect particles in front of a FTL ship so that they are scattered before the physical ship arrives. They can also withstand the impact of microparticles at certain speeds, but anything faster than 1000 AU/hr is more or less impossible to travel at completely safe without extremely sophisticated shields.

FTL Communications

Gate System - Messages utilize Gate infrastructure. Standard comms.
Burst Communication - A burst communication uses a tachyon system that sends communications out at a specified speed. The most sophisticated burst communications can travel at speeds of up to 1 LY/m. These communications can be intercepted and stopped by certain technology.
Quantum Entangled Comms - Enables a unique pair of devices to have instantaneous communications at any distance in the universe.